Enfermedad Cardiovascular y Perfil Lipídico en ancianos con factores de riesgo clásicos

Cardiovascular disease and lipid profile in elderly persons with classical risk factors

Authors

  • Verónica Cristina Jurado Melo
  • Víctor Patricio Gavilanes Saenz
  • Roberto Javier Caicedo Maya
  • Lucas García Orozco
  • Milagros Escalona Rabaza
  • Salomón Proaño Ramón
  • Guillermo Rodrigo Santillán Pilca

Keywords:

LDL cholesterol, cardiovascular risk, coronary syndrome

Abstract

To establish the association between the occurrence of coronary event and the lipid profile in elderly patients (over 70 years old) with typical risk factors. A comparative study was carried out, where 40 patients were assigned to the case group with coronary disease (AMI-Angina) and 80 patients to the control group without coronary disease, both groups without statistically significant differences with respect to different variables (age, gender, comorbidities). or smoking), attended at the Endocrinology Service of the Specialties Hospital of the Armed Forces Nº1 Quito-Ecuador. The association between coronary event and high values of low density lipoproteins was statistically significant (OR: 4, CI: 1.31-12.74, p <0.05), being higher in the group of 70 to 79 years (OR : 3.8) than in the 80 to 89 years (OR: 2.5). 62.5% of the patients in the case group who received lipidlowering treatment did not meet the low-density lipoprotein targets. However, there was no statistically significant difference between strict adherence to low density lipoprotein targets and the presence of coronary event (OR: 0.7 CI: 0.35-1.6), in patients over 80 years of age, although no statistically significant association was found in the levels of very low density lipoprotein, the triglyceride /HDL index and cardiovascular risk, as well as there was no association between compliance with low density lipoprotein targets and presence of coronary event ( OR: 0.7 CI: 0.35-1.6), in patients older than 80 years.

Downloads

Download data is not yet available.

References

Miettinen, T. A., Pyörälä, K., Olsson, A. G., Musliner, T. A., Cook, T. J., Faergeman, et al & Scandinavian Simvastatin Study Group. (1997). Cholesterol-lowering therapy in women and elderly patients with myocardial infarction or angina pectoris. Circulation, 96(12), 4211-4218.

Lewis et al. (1998). Effect of pravastatin on cardiovascular events in older patients with myocardial infarction and cholesterol levels in the average range. Results of the Cholesterol and Recurrent Events (CARE) trial. Ann Intern, 129(9):681-9.

Hunt, D., Young, P., Simes, J., Hague, W., Mann, S., Owensby et al. (2001). Benefits of pravastatin on cardiovascular events and mortality in older patients with coronary heart disease are equal to or exceed those seen in younger patients: results from the LIPID trial. Ann Intern Med, 134(10), 931-940.

Williams, L. (2002). Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation, 106(25), 3143-3143.

Grundy, S. M., Cleeman, J. I., Rifkind, B. M., & Kuller, L. H. (1999). Cholesterol lowering in the elderly population. Arch Intern Med, 159(15), 1670-1678.

Plana, N., Ibarretxe, D., Cabré, A., Ruiz, E., & Masana, L. (2014). Prevalence of atherogenic dyslipidemia in primary care patients at moderate-very high risk of cardiovascular disease. Cardiovascular risk perception. Clínica e Investigación en Arteriosclerosis, 26(6), 274-284.

Ferrara, A., Barrett-Connor, E., & Shan, J. (1997). Total, LDL, and HDL cholesterol decrease with age in older men and women. Circulation, 96(1), 37-43.

Ericsson, S., Eriksson, M., Vitols, S., Einarsson, K., Berglund, L., & Angelin, B. (1991). Influence of age on the metabolism of plasma low density lipoproteins in healthy males. J Clin Invest, 87(2), 591.

Houterman, S., Verschuren, W.M., Hofman, A., & Witteman, J. C. M. (1999). Serum cholesterol is a risk factor for myocardial infarction in elderly men and women: the Rotterdam Study. J Intern Med, 246(1), 25-33.

Bertsch,Merchant,et all.Study of the use of Lipid Panels as a Marker of insulin resistant to determine Cardiovascular Risk. PenJ,2015.19(4) 4-10 11. Castelli, W.P., Wilson, P.W., Levy, D., & Anderson, K. (1989). Cardiovascular risk factors in the elderly. Am J Cardiol, 63(16), 12-19.

Granado J (2010). Estudio EPIC. Colesterol y riesgo cardiaco. ( Más alla del LDL). J AM Coll Cardiology 55:35-41.

Cantore, J.A. (2015). Dislipidemia en ancianos. In Anales de la Facultad de Ciencias Médicas. Vol. 38, No. 1-2, pp. 63-67

Grundy, S. M., Bazzarre, T., Cleeman, J., & D’Agostino Sr, R. B. (2000). Hill 7. M, Houston-Miller N, et al. Prevention Conference V: beyond secondary prevention. Identifying the high-risk patient for primary prevention. Medical office assessment. Writing Group I. Circulation, 101, E3-E11

Corti, M.C., Guralnik, J.M., Salive, M. E., Harris, T., Field, T.S., Wallace, R.B et al. (1995). HDL cholesterol predicts coronary heart disease mortality in older persons. Jama, 274(7), 539-544.

Parish, S., Peto, R., Palmer, A., Clarke, R., Lewington, S., Offer, A. et al (2009). The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls. Eur Heart J, 30(17), 2137-2146.

Rubin SM, Sidney S, Black DM. High blood colesterol in ederly men the excess risk for coronary heart desease. Ann Inter Med. 1990;113:916-20

Weverling-Rijnsburger, A. W., Blauw, G. J., Lagaay, A. M., Knock, D. L., Meinders, A. E., & Westendorp, R. G. (1997). Total cholesterol and risk of mortality in the oldest old. The Lancet, 350(9085), 1119-1123.

Krumholz, H. M., Seeman, T. E., Merrill, S. S., de Leon, C. F. M., Vaccarino, V., Silverman, D. I., et al. (1994). Lack of association between cholesterol and coronary heart disease mortality and morbidity and all-cause mortality in persons older than 70 years. Jama, 272(17), 1335-1340.

Grundy, S. M., Cleeman, J. I., Merz, C. N. B., Brewer, H. B., Clark, L. T., Hunninghake, D. B., ... & Stone, N. J. (2004). Implications of recent clinical trials for the national cholesterol education program adult treatment panel III guidelines. Circulation, 110(2), 227-239.

Briongos S., Fernánde, S., Segura de la Cal, T., Casas, R., López, A., Marcos, J., Jimenez, M. & Zamorano, J.L. Importancia de las cifras de colesterol LDL en el pronóstico de pacientes tras un síndrome coronario agudo. Servicio de Cardiología del Hospital Universitario Ramón y Cajal. Madrid Rev Esp Cardiol. 2012;65 Supl 3:200

Binno, S. (2016). 2016 European Guidelines on cardiovascular disease prevention in clinical practiceiveros HL, Fundación FES. Cali, Colombia., Rodríguez-Amaya RM, et al. Factores asociados al embarazo en adolescentes de 13 a 19 años en el municipio de Buenaventura, Colombia. Rev Univ Ind Santander Salud. 1 de abril de 2017;49(2):290300.

Aramburú CE, Quincot RA. Dimensiones Culturales Del Embarazo En La Adolescencia.

Domínguez-Anaya R, Herazo-Beltrán Y, Sc M. Edad de la gestante adolescente como factor de riesgo para complicaciones en el embarazo. Cartagena (Colombia) 2009. Estudio de corte transversal Age as a risk factor for complications arising during pregnancy in adolescents, Cartagena, Colombia 2009: a cross-sectional study. :7

Published

2018-12-31

How to Cite

1.
Jurado Melo VC, Gavilanes Saenz VP, Caicedo Maya RJ, García Orozco L, Escalona Rabaza M, Proaño Ramón S, et al. Enfermedad Cardiovascular y Perfil Lipídico en ancianos con factores de riesgo clásicos: Cardiovascular disease and lipid profile in elderly persons with classical risk factors. lauinvestiga [Internet]. 2018 Dec. 31 [cited 2024 May 19];5(2):17-26. Available from: http://revistasojs.utn.edu.ec/index.php/lauinvestiga/article/view/420

Issue

Section

Original articles

Most read articles by the same author(s)

Similar Articles

<< < 1 2 3 4 > >> 

You may also start an advanced similarity search for this article.